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Praziquantel is an isoquinolone anthelmintic with the chemical name 2-(Cyclohexylcarbonyl)-1,2,3,6,7,-11b-hexahydro-4H-pyrazinoisoquinolin-4-one.

Benzoylphenylurea compounds, including lufenuron, are classified as insect development inhibitors (IDIs). Lufenuron is a benzoylphenylurea derivative with the following chemical composition: N-2,6-difluorobenzamide (C 17H 8Cl 2F 8N 2O 3, MW 511.15). Milbemycin oxime is classified as a macrocyclic anthelmintic. Milbemycin oxime consists of the oxime derivatives of 5-didehydromilbemycins in the ratio of approximately 80% A 4 (C 32H 45NO 7, MW 555.71) and 20% A 3 (C 31H 43NO 7, MW 541.68). Each chewable flavored tablet is formulated to provide a minimum of 0.23 mg/pound (0.5 mg/kg) of milbemycin oxime, 4.55 mg/pound (10 mg/kg) of lufenuron, and 2.28 mg/pound (5 mg/kg) of praziquantel. SENTINEL ® SPECTRUM ® Chews are available in four strengths in color-coded packages for oral administration to dogs and puppies according to their weight.